1st European Symposium on Myeloid Regulatory Cells in Health and Disease

1–3 November 2018 • Essen (Germany)

1st European Symposium on Myeloid Regulatory Cells in Health and Disease

1–3 November 2018 • Essen (Germany)

Congress details

Downloads

Print-File

Scientific programme

The conference will cover presentations of scientific milestones from four years of pan-European collaboration, and debates on controversial issues in MRC research.

Confirmed Speakers

  • Gosse Adema, Radboud University Medical Center (Nijmegen, NL)
  • Sven Brandau, University of Duisburg-Essen (Essen, DE)
  • Paul Frenette, Albert Einstein College of Medicine (New York City, NY/USA)
  • Dmitry Gabrilovich, Wistar Institute (Philadelphia, PA/USA)
  • Matthias Gunzer, University of Duisburg-Essen (Essen, DE)
  • Andres Hidalgo, Centro Nacional de Investigaciones Cardiovasculares (Madrid, Spain)
  • James Hutchinson, University Hospital Regensburg (Regensburg, DE)
  • Paul Kubes, University of Calgary (Calgary, Canada)
  • Tim Lämmermann, Max Planck Institute of Immunobiology and Epigenetics (Freiburg, DE)
  • Mihai Netea, Radboud University Medical Center (Nijmegen, NL)
  • Suzanne Ostrand-Rosenberg, University of Maryland (Baltimore, MD/USA)
  • Jeff Pollard, University of Edinburgh (Edinburgh, UK)
  • Joachim Schultze, University of Bonn (Bonn, DE)
  • Jo van Ginderachter, Vrije Universiteit Brussel (Brussels, BE)

The preliminary program can be found below.

Room Deichmann Auditorium
Time Programme Speaker
09.00 – 10.30 COST MC (Part 1) Closed Session for Mye-EUNITER members only
10.30 – 11.00 Coffee break  
11.00 – 13.00 COST MC/WG Meeting (Part 2) Closed Session for Mye-EUNITER members only
13.00 – 14.00 Lunch break  
14.00 – 15.00 Educational Programme H. Bauch, Carl Zeiss Microscopy GmbH: The new Power of Confocal Imaging: Combining Sensitivity, Speed and Superresolution
15.00 – 16.00 Official Opening of ESMRC
Keynote Lecture
Conference Chair
D. Gabrilovich: Neutrophils and PMN-MDSC in cancer – the tale of two cells
M. Netea: Trained immunity: long-term memory of myeloid cells
16.00 – 16.30 Coffee break  
16.30 – 18.00 Interaction with other cells

T. Lämmermann: Imaging Myeloid Cell Dynamics at Local Site of Inflammation and Infection
E. Marin: Human tolerogenic dendritic cells regulate immune response through lactate synthesis and regulatory T cell induction
A. Bruger: Mye-FUN – standardizing T cell proliferation assays to assess MDSC suppressive functions
C. Aarts: Activated neutrophils suppress T lymphocyte proliferation: mechanisms unraveled

18.00 – 20.00 Poster Session Poster Exhibition
Room Hörsaal IG 1 (LLZ) – Parallel Session 1
Time Programme Speaker
09.00 – 10.30 Autoimmunity & TransplantationJ. Hutchinson: TIGIT and iTregs elicited by human regulatory macrophages control T cell immunity
N. Maugeri: Defective clearance of activated platelets in SLE and other systemic autoimmune diseases reflects increased NETs generation
J. Scheurer: Graft-versus-host disease (GVHD) prevention without disabling graft-versus-tumor (GVT) effect by in vitro-generated myeloid-derived suppressor cells (MDSCs) is mediated by the CD11b+CD11c+ subpopulation
D. D. Le: Non-classical monocyte derived host macrophages protect against murine intestinal acute graft-versus-host disease
10.30 – 11.00 Coffee break  
11.00 – 13.00 Cellular Plasticity (Mye-EUNITER Session)J. Pollard: Macrophages: Bad Actors in Cancer
J. van Ginderachter: Heterogeneity of macrophages and dendritic cells in the tumor microenvironment
K. Yu: Targeting regulatory macrophages to lymph nodes for suppressing undesired immune responses by forced overexpression of CCR7
L. Wang: Function, molecular control and clinical relevance of a candidate pathogenic neutrophil subset associated with auto-immune rheumatic diseases
A. Ohradanova-Repic: Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances
13.00 – 14.00 Lunch break
Room 0.38 Robert-Koch-Haus – Parallel Session 2
Time Programme Speaker
09.00 – 10.30 Cancer & inflammation (Part 1)S. Ostrand-Rosenberg: Diet-driven myeloid-derived suppressor cells: upsides and downsides for metabolism and cancer
D. Gyori: Compensation between CSF1R+ tumour-associated macrophages and Foxp3+ regulatory T cells drives resistance to cancer immunotherapy
P. Metzger: Irf4-deficiency expands myeloid cells and accelerates tumor growth in an orthotopic pancreatic cancer model
C. Neander: Effects of Trametinib on Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma
10.30 – 11.00 Coffee break  
11.00 – 13.00 Cancer & inflammation (Part 2) (Mye-EUNITER Session)S. Brandau: MDSC and neutrophil functional subsets
G. Adema: Cancer Vaccine Adjuvants, Myeloid cell subsets and antigen cross-presentation
N. Vijitha: Chronic lymphocytic leukemia reduces the maturation and the anti-microbial capacity of neutrophils through TGF-beta
E. Tavukcuoglu: Analysis of spleen-derived MDSCs in pancreatic and gastric cancer patients
X. Hu: Tumor-derived extracellular vesicles mediate the conversion of myeloid cells into MDSCs in malignant melanoma
13.00 – 14.00 Lunch break  
Room Deichmann Auditorium
Time Programme Speaker
14.00 – 16.00 Myelopoiesis and Molecular RegulationA. Hidalgo: A look at neutrophils across time and space
J. Schultze: The myeloid cell compartment newly mapped by single cell genomics
J. Font-Diaz: Transcriptomic characterization of the effects of LXR activation in tumour associated macrophages
L. Fischer-Riepe: Murine scavenger receptor CD163 is a marker for a specific IRF8-dependent resident macrophage subpopulation in the bone marrow
T. Alissafi: Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells
16.00 – 16.30 Coffee break  
16.30 – 18.00 Microbiota, Pathogen Recognition & Vaccination P. Frenette: Microbiota and neutrophil function: It's on your mind
T. Regen: Loss of IL-17A/F-mediated control of gut microbiota confers resistance to CNS autoimmunity
M. Lutz: Repeated mycobacteria vaccination in mice induces myeloid-derived suppressor cell killing of splenic dendritic cells via iNOS-dependent NO production
K. Serre: Different TLR signalling pathways induce macrophages or neutrophils with anti-tumour functions in vivo
18.00 – 19.30 Round Table – The myeloid cell family in disease: functional status vs distinct cell subsetsS. Brandau
Z. Fridlender
D. Gabrilovich
J. Pollard
V. Umansky
J. van Ginderachter
Room Deichmann Auditorium
Time Programme Speaker
09.00 – 10.30 Oral presentations selected from posters To be announced during ESMRC proceedings
10.30 – 11.00 Coffee break  
11.00 – 13.00 Infection and inflammationM. Gunzer: Defining the roads travelled by neutrophils to reach inflamed sites
C. Lamsfus Calle: Controlled human malaria infection with Plasmodium falciparum triggers an early increase in myeloid-derived suppressor cells in peripheral blood
G. Zelinskyy: Compensatory effects of inhibitory mechanisms during immunotherapy of retroviral infection 
K. Kienle: Signal adaptation controls neutrophil swarming dynamics at local sites of inflammation and infection
13.00 – 14.00 Lunch break  
14.00 – 15.00 Farewell Session P. Kubes: Imaging Myeloid Cells that Heal