1st European Symposium on Myeloid Regulatory Cells in Health and Disease
1–3 November 2018 • Essen (Germany)
1st European Symposium on Myeloid Regulatory Cells in Health and Disease
1–3 November 2018 • Essen (Germany)
Scientific programme
The conference will cover presentations of scientific milestones from four years of pan-European collaboration, and debates on controversial issues in MRC research.
Confirmed Speakers
- Gosse Adema, Radboud University Medical Center (Nijmegen, NL)
- Sven Brandau, University of Duisburg-Essen (Essen, DE)
- Paul Frenette, Albert Einstein College of Medicine (New York City, NY/USA)
- Dmitry Gabrilovich, Wistar Institute (Philadelphia, PA/USA)
- Matthias Gunzer, University of Duisburg-Essen (Essen, DE)
- Andres Hidalgo, Centro Nacional de Investigaciones Cardiovasculares (Madrid, Spain)
- James Hutchinson, University Hospital Regensburg (Regensburg, DE)
- Paul Kubes, University of Calgary (Calgary, Canada)
- Tim Lämmermann, Max Planck Institute of Immunobiology and Epigenetics (Freiburg, DE)
- Mihai Netea, Radboud University Medical Center (Nijmegen, NL)
- Suzanne Ostrand-Rosenberg, University of Maryland (Baltimore, MD/USA)
- Jeff Pollard, University of Edinburgh (Edinburgh, UK)
- Joachim Schultze, University of Bonn (Bonn, DE)
- Jo van Ginderachter, Vrije Universiteit Brussel (Brussels, BE)
The preliminary program can be found below.
| Room Deichmann Auditorium | ||
| Time | Programme | Speaker |
| 09.00 – 10.30 | COST MC (Part 1) | Closed Session for Mye-EUNITER members only |
| 10.30 – 11.00 | Coffee break | |
| 11.00 – 13.00 | COST MC/WG Meeting (Part 2) | Closed Session for Mye-EUNITER members only |
| 13.00 – 14.00 | Lunch break | |
| 14.00 – 15.00 | Educational Programme | H. Bauch, Carl Zeiss Microscopy GmbH: The new Power of Confocal Imaging: Combining Sensitivity, Speed and Superresolution |
| 15.00 – 16.00 | Official Opening of ESMRC Keynote Lecture | Conference Chair D. Gabrilovich: Neutrophils and PMN-MDSC in cancer – the tale of two cells M. Netea: Trained immunity: long-term memory of myeloid cells |
| 16.00 – 16.30 | Coffee break | |
| 16.30 – 18.00 | Interaction with other cells | T. Lämmermann: Imaging Myeloid Cell Dynamics at Local Site of Inflammation and Infection |
| 18.00 – 20.00 | Poster Session | Poster Exhibition |
| Room Hörsaal IG 1 (LLZ) – Parallel Session 1 | ||
| Time | Programme | Speaker |
| 09.00 – 10.30 | Autoimmunity & Transplantation | J. Hutchinson: TIGIT and iTregs elicited by human regulatory macrophages control T cell immunity N. Maugeri: Defective clearance of activated platelets in SLE and other systemic autoimmune diseases reflects increased NETs generation J. Scheurer: Graft-versus-host disease (GVHD) prevention without disabling graft-versus-tumor (GVT) effect by in vitro-generated myeloid-derived suppressor cells (MDSCs) is mediated by the CD11b+CD11c+ subpopulation D. D. Le: Non-classical monocyte derived host macrophages protect against murine intestinal acute graft-versus-host disease |
| 10.30 – 11.00 | Coffee break | |
| 11.00 – 13.00 | Cellular Plasticity (Mye-EUNITER Session) | J. Pollard: Macrophages: Bad Actors in Cancer J. van Ginderachter: Heterogeneity of macrophages and dendritic cells in the tumor microenvironment K. Yu: Targeting regulatory macrophages to lymph nodes for suppressing undesired immune responses by forced overexpression of CCR7 L. Wang: Function, molecular control and clinical relevance of a candidate pathogenic neutrophil subset associated with auto-immune rheumatic diseases A. Ohradanova-Repic: Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances |
| 13.00 – 14.00 | Lunch break | |
| Room 0.38 Robert-Koch-Haus – Parallel Session 2 | ||
| Time | Programme | Speaker |
| 09.00 – 10.30 | Cancer & inflammation (Part 1) | S. Ostrand-Rosenberg: Diet-driven myeloid-derived suppressor cells: upsides and downsides for metabolism and cancer D. Gyori: Compensation between CSF1R+ tumour-associated macrophages and Foxp3+ regulatory T cells drives resistance to cancer immunotherapy P. Metzger: Irf4-deficiency expands myeloid cells and accelerates tumor growth in an orthotopic pancreatic cancer model C. Neander: Effects of Trametinib on Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma |
| 10.30 – 11.00 | Coffee break | |
| 11.00 – 13.00 | Cancer & inflammation (Part 2) (Mye-EUNITER Session) | S. Brandau: MDSC and neutrophil functional subsets G. Adema: Cancer Vaccine Adjuvants, Myeloid cell subsets and antigen cross-presentation N. Vijitha: Chronic lymphocytic leukemia reduces the maturation and the anti-microbial capacity of neutrophils through TGF-beta E. Tavukcuoglu: Analysis of spleen-derived MDSCs in pancreatic and gastric cancer patients X. Hu: Tumor-derived extracellular vesicles mediate the conversion of myeloid cells into MDSCs in malignant melanoma |
| 13.00 – 14.00 | Lunch break | |
| Room Deichmann Auditorium | ||
| Time | Programme | Speaker |
| 14.00 – 16.00 | Myelopoiesis and Molecular Regulation | A. Hidalgo: A look at neutrophils across time and space J. Schultze: The myeloid cell compartment newly mapped by single cell genomics J. Font-Diaz: Transcriptomic characterization of the effects of LXR activation in tumour associated macrophages L. Fischer-Riepe: Murine scavenger receptor CD163 is a marker for a specific IRF8-dependent resident macrophage subpopulation in the bone marrow T. Alissafi: Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells |
| 16.00 – 16.30 | Coffee break | |
| 16.30 – 18.00 | Microbiota, Pathogen Recognition & Vaccination | P. Frenette: Microbiota and neutrophil function: It's on your mind T. Regen: Loss of IL-17A/F-mediated control of gut microbiota confers resistance to CNS autoimmunity M. Lutz: Repeated mycobacteria vaccination in mice induces myeloid-derived suppressor cell killing of splenic dendritic cells via iNOS-dependent NO production K. Serre: Different TLR signalling pathways induce macrophages or neutrophils with anti-tumour functions in vivo |
| 18.00 – 19.30 | Round Table – The myeloid cell family in disease: functional status vs distinct cell subsets | S. Brandau Z. Fridlender D. Gabrilovich J. Pollard V. Umansky J. van Ginderachter |
| Room Deichmann Auditorium | ||
| Time | Programme | Speaker |
| 09.00 – 10.30 | Oral presentations selected from posters | To be announced during ESMRC proceedings |
| 10.30 – 11.00 | Coffee break | |
| 11.00 – 13.00 | Infection and inflammation | M. Gunzer: Defining the roads travelled by neutrophils to reach inflamed sites C. Lamsfus Calle: Controlled human malaria infection with Plasmodium falciparum triggers an early increase in myeloid-derived suppressor cells in peripheral blood G. Zelinskyy: Compensatory effects of inhibitory mechanisms during immunotherapy of retroviral infection K. Kienle: Signal adaptation controls neutrophil swarming dynamics at local sites of inflammation and infection |
| 13.00 – 14.00 | Lunch break | |
| 14.00 – 15.00 | Farewell Session | P. Kubes: Imaging Myeloid Cells that Heal |